RESUMO
An effort is made to critically present the achievements in silver ion chromatography during the last decade. Novelties in columns, mobile-phase compositions and detectors are described. Recent applications of silver ion chromatography in the analysis of fatty acids and triacylglycerols are presented while stressing novel analytical strategies or new objects. The tendencies in the application of the method in complementary ways with reversed-phase chromatography, chiral chromatography and, especially, mass detection are outlined.
Assuntos
Ácidos Graxos/análise , Prata/química , Triglicerídeos/análise , Cromatografia Líquida de Alta Pressão/história , Cromatografia em Camada Fina/história , Ácidos Graxos/história , História do Século XXI , Íons/química , Íons/história , Prata/história , Extração em Fase Sólida/história , Triglicerídeos/históriaRESUMO
This memoir provides a history of the triglyceride-rich lipoproteins of blood plasma over the last half-century. As precursors of low-density lipoproteins and in their own right, triglyceride-rich lipoproteins are essential to the formation of atherosclerotic plaques and to consequent ischemic vascular disease. The author recounts research at the National Heart Institute during 1953 to 1956 and continuing thereafter at the University of California San Francisco. Emphasis is placed on key insights arising from investigations of human disease, the interplay of fatty acid and triglyceride-transport involving the liver, small intestine, adipose tissue and muscle, and the role of the liver in the synthesis and catabolism of atherogenic lipoproteins.
Assuntos
Pesquisa Biomédica/história , Doenças Cardiovasculares/história , Lipoproteínas/história , Triglicerídeos/história , Animais , História do Século XX , Humanos , São FranciscoRESUMO
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